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Ring finger protein 19B

From Wikipedia, the free encyclopedia
RNF19B
Identifiers
AliasesRNF19B, IBRDC3, NKLAM, ring finger protein 19B
External IDsOMIM: 610872; MGI: 1922484; HomoloGene: 34999; GeneCards: RNF19B; OMA:RNF19B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001127361
NM_001300826
NM_153341

NM_029219
NM_001368763

RefSeq (protein)

NP_001120833
NP_001287755
NP_699172

NP_083495
NP_001355692

Location (UCSC)Chr 1: 32.94 – 32.96 MbChr 4: 128.95 – 128.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ring finger protein 19B is a protein that in humans is encoded by the RNF19B gene. [5]

Function

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This gene encodes a multi-pass membrane protein containing two RING-type and one IBR-type zinc finger motifs. The encoded protein is an E3 ubiquitin-protein ligase that plays a role in the cytotoxic effects of natural killer (NK) cells. Alternative splicing results in multiple transcript variants. There are pseudogenes for this gene on chromosomes X and Y in a possible pseudoautosomal region.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116514Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028793Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Ring finger protein 19B". Retrieved 2017-08-04.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.